INHIBITING EZH2 TARGETS ATYPICAL TERATOID RHABDOID TUMOR BY TRIGGERING VIRAL MIMICRY VIA BOTH RNA AND DNA SENSING PATHWAYS

Inhibiting EZH2 targets atypical teratoid rhabdoid tumor by triggering viral mimicry via both RNA and DNA sensing pathways

Abstract Inactivating mutations in SMARCB1 confer an oncogenic dependency on EZH2 in atypical teratoid rhabdoid tumors (ATRTs), but the underlying mechanism has not been fully elucidated.We found that the sensitivity of ATRTs to EZH2 inhibition (EZH2i) is associated with the viral mimicry response.Unlike other epigenetic therapies targeting transcr

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Rostral migration of intradural bullet from lumbar to thoracic spine: Case report and review of the literature

Migration of bullet in the canal is rare and intradural migration is even rarer.Most migration are caudal to the site of trauma.This case presents present a case of 27 years old man who sustained a bullet injury WRIST PAIN on his back at L1 with no exit site.He was having generalized tenderness on his abdomen and complete neurologic injury below th

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Lacrimal gland removal impairs sexual behavior in mice

Exocrine gland-secreting peptides (ESPs) are a protein family involved in the pheromonal communication of rodents.ESP1 is a lacrimal peptide synthesized by the extraorbital glands of males of specific mouse strains that modulates the sexual behavior in females.Reportedly, BALB/c males, that produce high level of ESP1 in the tear fluid, were shown t

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Arhinops, a new name for the genus Arhina Murray, 1876, non Arhina Agassiz, 1846 (Insecta: Diptera), and notes on the tribe Arhinopini nom. n. (Insecta: Coleoptera: Nitidulidae: Cryptarchinae)

The genus-group name Arhina Murray, 1876 has been used as valid for a group of beetles Vitamins B in the family Nitidulidae.Indeed this name is preoccupied by the available name Arhina Agassiz, 1846 (Insecta: Diptera).Arhinops nom.n.is hereby proposed as a replacement name for Arhina Murray, 1876.Correspondingly the tribal name Arhinini Kirejtshuk,

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